| Gene | Pathway | Effect | Variants | Reports |
|---|---|---|---|---|
| PIK3CA | PI3K-AKT | loss of function | 25 | |
| PIK3CD | PI3K-AKT | gain of function | 1 | |
| PIK3R1 | PI3K-AKT | gain of function | 1 | |
| KRAS | RAS-MAPK | gain of function | 8 | |
| HRAS | RAS-MAPK | gain of function | 3 | |
| NRAS | RAS-MAPK | gain of function | 4 | |
| ARAF | RAS-MAPK | gain of function | 1 | |
| BRAF | RAS-MAPK | gain of function | 4 | |
| CBL | RAS-MAPK | loss of function | 1 | |
| MAP2K1 | RAS-MAPK | gain of function | 1 |